SCHEMBL30985120

SCHEMBL30985120

O=C1CCC(N2Cc3cc(N4CCC5(CCC(CO)CC5)CC4)ccc3C2=O)C(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 10/20 0.58
▸ ESR1 P03372 1/20 0.49
▸ WIZ O95785 1/20 0.49
▸ CSNK1A1 P48729 1/20 0.49
▸ IKZF2 Q9UKS7 9/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30984966 0.95 CRBN (0.56) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL30984858 0.95 CRBN (0.56) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL30985009 0.93 CRBN (0.58) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL30984736 0.92 CRBN (0.59) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL20234982 0.91 CRBN (0.63) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL29614522 0.91 CRBN (0.63) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL22498051 0.89 CRBN (0.59) CRBNWIZCSNK1A1IKZF2
Hydrochloric Acid SCHEMBL31726759 0.88 CRBN (0.58) CRBNESR1WIZCSNK1A1IKZF2
Hydrochloric Acid SCHEMBL31204436 0.88 CRBN (0.58) CRBNESR1WIZCSNK1A1IKZF2
SCHEMBL30984859 0.87 CRBN (0.56) CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024146502-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2024-07-11 — — WO disclosed
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