SCHEMBL30985214

SCHEMBL30985214

O=C1CCC(N2Cc3cc(-c4cnn(C5CCC6(CC5)CNC6)c4)ccc3C2=O)C(=O)N1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 11/20 0.52
▸ IKZF2 Q9UKS7 7/20 0.46
▸ IKZF1 Q13422 2/20 0.46
▸ CSNK1A1 P48729 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30984869 0.89 CRBN (0.55) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL20235033 0.88 CRBN (0.56) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL30984737 0.87 CRBN (0.51) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL30984866 0.85 CRBN (0.52) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL30985154 0.83 CRBN (0.45) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL30984956 0.82 CRBN (0.55) CRBN
SCHEMBL27313191 0.81 CRBN (0.52) CRBNIKZF2IKZF1
SCHEMBL27313591 0.80 CRBN (0.50) CRBNIKZF2IKZF1
SCHEMBL27323900 0.80 CRBN (0.50) CRBNIKZF2IKZF1
SCHEMBL20235032 0.78 CRBN (0.49) CRBNIKZF2IKZF1CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024146502-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2024-07-11 — — WO disclosed
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