Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Padoprazan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Padoprazan SCHEMBL30250197 | 0.93 | AVPR2 (0.39) | AVPR2OXTRAVPR1ANAMPTGCK | |
| Padoprazan SCHEMBL25225599 | 0.93 | AVPR2 (0.39) | AVPR2OXTRAVPR1ANAMPTGCK | |
| SCHEMBL30250036 | 0.84 | SLC6A2 (0.35) | MEN1KMT2AHTR6 | |
| SCHEMBL28996377 | 0.84 | SLC6A2 (0.35) | MEN1KMT2AHTR6 | |
| Fumaric Acid SCHEMBL2408204 | 0.83 | NAMPT (0.37) | AVPR2OXTRAVPR1ANAMPTEIF2AK3 | |
| Fumaric Acid SCHEMBL2408214 | 0.83 | NAMPT (0.37) | AVPR2OXTRAVPR1ANAMPTEIF2AK3 | |
| SCHEMBL30250130 | 0.83 | MEN1 (0.37) | OXTRAVPR1AGCKEIF2AK3MEN1 | |
| SCHEMBL26650833 | 0.83 | MEN1 (0.37) | OXTRAVPR1AGCKEIF2AK3MEN1 | |
| SCHEMBL31522099 | 0.81 | AVPR2 (0.40) | AVPR2OXTRAVPR1ANAMPTGCK | |
| SCHEMBL26697786 | 0.81 | AVPR2 (0.40) | AVPR2OXTRAVPR1ANAMPTGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365448-A | Preparation method of 6-methoxypyridine-3-yl derivative | 日东制药株式会社 | 2025-01-24 | — | — | CN | disclosed |
| CN-118401510-A | Novel salts of 1-sulfonylpyrrole derivatives, process for preparing the same and pharmaceutical compositions containing the same | 日东制药株式会社 | 2024-07-26 | — | — | CN | disclosed |