Padoprazan

Padoprazan

SCHEMBL25225599

CNCc1cn(S(=O)(=O)c2ccc(OC)nc2)c(-c2ccccc2F)c1OC

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AVPR2 P30518 1/20 0.39
▸ OXTR P30559 1/20 0.39
▸ AVPR1A P37288 1/20 0.39
▸ EPHB4 P54760 1/20 0.37
▸ EIF2AK3 Q9NZJ5 1/20 0.36
▸ GCK P35557 1/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ PABPC1 P11940 1/20 0.34
▸ TSHR P16473 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ USP2 O75604 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ NAMPT P43490 4/20 0.34
▸ PTGS1 P23219 1/20 0.33
▸ PTGS2 P35354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Padoprazan SCHEMBL30250197 1.00 AVPR2 (0.39) AVPR2OXTRAVPR1AEPHB4EIF2AK3
Padoprazan SCHEMBL30985953 0.93 AVPR2 (0.36) AVPR2OXTRAVPR1AEPHB4EIF2AK3
SCHEMBL30250036 0.91 SLC6A2 (0.35) MEN1KMT2ATSHRSMN1; SMN2HTT
SCHEMBL28996377 0.91 SLC6A2 (0.35) MEN1KMT2ATSHRSMN1; SMN2HTT
SCHEMBL26650833 0.89 MEN1 (0.37) OXTRAVPR1AEIF2AK3GCKMEN1
SCHEMBL30250130 0.89 MEN1 (0.37) OXTRAVPR1AEIF2AK3GCKMEN1
SCHEMBL30427346 0.83 MEN1 (0.36) OXTRAVPR1AMEN1KMT2APABPC1
SCHEMBL30287347 0.82 KMT2A (0.41) AVPR2OXTRAVPR1AEPHB4EIF2AK3
SCHEMBL25228488 0.82 KMT2A (0.41) AVPR2OXTRAVPR1AEPHB4EIF2AK3
SCHEMBL29241023 0.82 KAT6A (0.34) PTGS1PTGS2HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250084026-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2025-03-13 — — US claimed
US-20250042872-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME ILDONG PHARMACEUTICAL CO., LTD. (KR) 2025-02-06 — — US claimed
CN-115884968-B Novel acid secretion inhibitor and use thereof 日东制药株式会社 2024-06-21 — — CN claimed
US-20230373954-A1 NOVEL ACID SECRETION INHIBITOR AND USE THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-11-23 — — US claimed
WO-2023113458-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-06-22 — — WO claimed
CN-115884968-A Novel acid secretion inhibitor and use thereof 日东制药株式会社 2023-03-31 — — CN claimed
US-20250084026-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2025-03-13 — — US disclosed
US-20250042872-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME ILDONG PHARMACEUTICAL CO., LTD. (KR) 2025-02-06 — — US disclosed
CN-115884968-B Novel acid secretion inhibitor and use thereof 日东制药株式会社 2024-06-21 — — CN disclosed
WO-2023229322-A1 METHOD FOR PREPARING 6-METHOXYPYRIDIN-3-YL DERIVATIVES 일동제약(주) 2023-11-30 — — WO disclosed
US-11767311-B2 Acid secretion inhibitor and use thereof ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-09-26 — — US disclosed
US-20230192650-A1 NOVEL ACID SECRETION INHIBITOR AND USE THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-06-22 — — US disclosed
WO-2023113458-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-06-22 — — WO disclosed
WO-2023113474-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 일동제약(주) 2023-06-22 — — WO disclosed
CN-115884968-A Novel acid secretion inhibitor and use thereof 日东制药株式会社 2023-03-31 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11767311-B2 Acid secretion inhibitor and use thereof SLC10A2, SLC10A1, ASIC1 AVPR2 34/4885OXTR 3336/4885AVPR1A 527/4885
US-20250084026-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF ABCG2, SLC7A1, SLC34A1 AVPR2 303/4885OXTR 3536/4885AVPR1A 407/4885
US-20250042872-A1 NOVEL SALT OF 1-SULFONYL PYRROLE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME SRM, SLC7A1, SLC20A1 AVPR2 557/4885OXTR 3456/4885AVPR1A 686/4885
US-20230373954-A1 NOVEL ACID SECRETION INHIBITOR AND USE THEREOF SLC10A2, SLC10A1, ASIC1 AVPR2 41/4885OXTR 3292/4885AVPR1A 618/4885
US-20230192650-A1 NOVEL ACID SECRETION INHIBITOR AND USE THEREOF SLC10A2, SLC10A1, ASIC1 AVPR2 41/4885OXTR 3292/4885AVPR1A 618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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