Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 4/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.43 |
| ▸ | GABRP | O00591 | 3/20 | 0.43 |
| ▸ | GABRD | O14764 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.43 |
| ▸ | GABRE | P78334 | 3/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3111341 | 0.86 | GABRA2 (0.41) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL6055741 | 0.82 | GABRA2 (0.45) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL3106252 | 0.80 | GABRA2 (0.43) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL6055865 | 0.78 | GABRA2 (0.45) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9171845 | 0.78 | GABRA2 (0.45) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL28073862 | 0.78 | GABRA2 (0.42) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9168117 | 0.77 | GABRA2 (0.44) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL3111216 | 0.76 | GABRP (0.59) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL3107735 | 0.76 | GABRA2 (0.41) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL6555658 | 0.75 | GABRA2 (0.46) | GABRA2GABRB2GABRB3GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | claimed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | claimed |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER INC. (US) | 2010-03-25 | — | — | US | claimed |
| US-20080261940-A1 | N-(1-Arylpyrazol-4L) Sulfonamides and their Use as Parasiticides | ZOETIS LLC | 2008-10-23 | — | — | US | claimed |
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20080261940-A1 | N-(1-Arylpyrazol-4L) Sulfonamides and their Use as Parasiticides | ZOETIS LLC | 2008-10-23 | — | — | US | disclosed |
| US-20080261940-A1 | N-(1-Arylpyrazol-4L) Sulfonamides and their Use as Parasiticides | ZOETIS LLC | 2008-10-23 | — | — | US | disclosed |
| US-20080261940-A1 | N-(1-Arylpyrazol-4L) Sulfonamides and their Use as Parasiticides | ZOETIS LLC | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | ARSA, STS, SULT1E1 | GABRA2 2277/4885GABRB2 2822/4885GABRB3 2768/4885 |
| US-20080261940-A1 | N-(1-Arylpyrazol-4L) Sulfonamides and their Use as Parasiticides | ARSA, STS, SULT1E1 | GABRA2 2277/4885GABRB2 2822/4885GABRB3 2768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.