Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986800 | 0.75 | KDR (0.41) | DGAT1KDRPDE10AKCNN3 | |
| SCHEMBL239388 | 0.74 | PDE4A (0.49) | PDE4A | |
| SCHEMBL11931247 | 0.72 | MAPT (0.48) | KDRPDE4A | |
| SCHEMBL238498 | 0.72 | KDR (0.40) | MAPKAPK2DGAT1KDRPDE10AMBOAT4 | |
| SCHEMBL236943 | 0.69 | KDR (0.40) | DGAT1KDRPDE10A | |
| SCHEMBL21863419 | 0.68 | PDE4A (0.41) | DGAT1KDRPDE4A | |
| SCHEMBL4431791 | 0.68 | ALDH1A1 (0.50) | KDRPDE10A | |
| SCHEMBL236467 | 0.66 | RAB9A (0.64) | — | |
| SCHEMBL7460875 | 0.66 | KDR (0.38) | DGAT1KDRPDE4APDE10AKCNN3 | |
| SCHEMBL15690215 | 0.66 | PDE10A (0.44) | MAPKAPK2DGAT1KDRPDE10AKCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |