SCHEMBL30988959

SCHEMBL30988959

Cc1ccc(S(N)(=O)=O)c(Cc2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGES2 Q9H7Z7 3/20 0.46
BCHE P06276 1/20 0.44
ACHE P22303 1/20 0.44
KIF11 P52732 2/20 0.43
KMT2A Q03164 1/20 0.43
HSP90AA1 P07900 1/20 0.42
IDH1 O75874 1/20 0.42
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA9 Q16790 3/20 0.41
CA5A P35218 1/20 0.41
PTGS2 P35354 2/20 0.39
MCL1 Q07820 1/20 0.39
CA12 O43570 2/20 0.39
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29988464 0.83 BCHE (0.47) PTGES2BCHEACHECA1CA2
SCHEMBL1700674 0.81 MEN1 (0.44) KMT2AIDH1CA1CA2CA9
SCHEMBL30988955 0.81 MEN1 (0.44) KMT2AIDH1CA1CA2CA9
SCHEMBL29988930 0.80 PTGES2 (0.45) PTGES2KIF11KMT2ACA1CA2
SCHEMBL29988503 0.79 ALDH1A1 (0.43) BCHEACHEKMT2AIDH1CA1
SCHEMBL20478174 0.76 PTGS2 (0.41) PTGES2KMT2ACA1CA2CA9
SCHEMBL28335961 0.76 IDH1 (0.35) BCHEACHEKMT2AHSP90AA1IDH1
SCHEMBL30738460 0.74 ALK (0.44) PTGES2KMT2ACA1CA2CA9
SCHEMBL30486842 0.74 PTGS2 (0.41) PTGES2KMT2ACA1CA2CA9
SCHEMBL20478179 0.74 TAAR1 (0.42) PTGES2KMT2ACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118344268-A Synthesis method of N-alkyl sulfonamide 四川轻化工大学 2024-07-16 CN disclosed