Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 7/20 | 0.37 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990450 | 0.88 | RET (0.51) | RETKDREGFRBTK | |
| SCHEMBL30990430 | 0.84 | RET (0.53) | RETEGFRBTK | |
| SCHEMBL30990436 | 0.84 | RET (0.54) | RETKDREGFRBTK | |
| SCHEMBL30990426 | 0.82 | RET (0.51) | RETEGFRBTK | |
| SCHEMBL30990492 | 0.80 | RET (0.46) | RETKDREGFRBTK | |
| SCHEMBL30990490 | 0.80 | RET (0.46) | RETKDREGFRBTK | |
| SCHEMBL30990497 | 0.79 | RET (0.39) | RETKDREGFRBTK | |
| SCHEMBL30990486 | 0.75 | RET (0.53) | RETBTK | |
| SCHEMBL30990471 | 0.75 | RET (0.53) | RETBTK | |
| SCHEMBL30990418 | 0.73 | RET (0.54) | RETKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665720-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173832-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |