Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25214363 | 0.82 | PDE4D (0.41) | GPR119FAAHPDE4APDE4BPDE4C | |
| SCHEMBL947678 | 0.78 | GPR119 (0.50) | GPR119HCAR1JAK2JAK1TYK2 | |
| SCHEMBL25218107 | 0.78 | GPR119 (0.41) | GPR119FAAHPDE4APDE4BPDE4C | |
| SCHEMBL15525325 | 0.78 | DDB1 (0.48) | GPR119JAK2JAK3PDE4APDE4B | |
| SCHEMBL25626286 | 0.78 | GPR119 (0.47) | GPR119FAAHHCAR1JAK2JAK1 | |
| SCHEMBL27460187 | 0.77 | GPR119 (0.49) | GPR119HCAR1JAK2JAK1TYK2 | |
| SCHEMBL1799144 | 0.77 | CTSD (0.49) | GPR119HCAR1CTSDCTSEBACE1 | |
| SCHEMBL31591369 | 0.77 | GPR119 (0.32) | GPR119FAAH | |
| SCHEMBL1555054 | 0.76 | GPR119 (0.48) | GPR119HCAR1JAK2JAK1TYK2 | |
| SCHEMBL8623093 | 0.76 | GPR119 (0.49) | GPR119HCAR1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665720-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173832-A2 | ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |