Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27902970 | 0.97 | GSR (0.40) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Arginine SCHEMBL28224022 | 0.95 | OTC (0.42) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL27832725 | 0.92 | OTC (0.39) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL17968364 | 0.92 | OTC (0.39) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL5058311 | 0.91 | GSR (0.51) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Arginine SCHEMBL28104030 | 0.89 | SLC1A3 (0.44) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Arginine SCHEMBL25212883 | 0.89 | OTC (0.47) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL4586458 | 0.89 | OTC (0.47) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL4586460 | 0.89 | OTC (0.47) | GSRCYP1A2OTCNOS1NOS3 | |
| Arginine SCHEMBL6703685 | 0.88 | OTC (0.42) | GSRCYP1A2OTCNOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9050176-B2 | At least partially resorbable reticulated elastomeric matrix elements and methods of making same | BIOMERIX CORPORATION (US) | 2015-06-09 | — | — | US | disclosed |
| US-8801801-B2 | At least partially resorbable reticulated elastomeric matrix elements and methods of making same | BIOMERIX CORPORATION (US) | 2014-08-12 | — | — | US | disclosed |
| US-20120239161-A1 | AT LEAST PARTIALLY RESORBABLE RETICULATED ELASTOMERIC MATRIX ELEMENTS AND METHODS OF MAKING SAME | BIOMERIX CORPORATION (US) | 2012-09-20 | — | — | US | disclosed |
| US-20100256777-A1 | At least partially resorbable reticulated elastomeric matrix elements and methods of making same | BIOMETRIX CORPORATION (US) | 2010-10-07 | — | — | US | disclosed |