Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | GRM8 | O00222 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.51 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL2582854 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL424415 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL577728 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL4749671 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578155 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6803653 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578156 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL573880 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL150228 | 0.94 | OTC (0.49) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6672058 | 0.94 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407208-B1 | PEPTIDES WITH AMINO ACID SEQUENCES | EXECUTIVE YUAN-COUNCIL OF AGRICULTURE (TW) | 2002-06-18 | — | — | US | claimed |
| US-20080070791-A1 | Libraries Of Chimeric Cellulose Binding Proteins And Methods Of Use Thereof | ZEPHYR PROTEOMIX LTD. (IL) | 2008-03-20 | — | — | US | disclosed |
| EP-1565744-A4 | MICROARRAYS OF CELLULOSE BINDING CHIMERIC PROTEINS AND METHODS OF USE THEREOF | ZEPHYR PROTEOMIX LTD (IL) | 2007-06-20 | — | — | EP | disclosed |
| EP-1682661-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| EP-1565744-A2 | MICROARRAYS OF CELLULOSE BINDING CHIMERIC PROTEINS AND METHODS OF USE THEREOF | Zephyr Proteomix Ltd. (IL) | 2005-08-24 | — | — | EP | disclosed |
| US-20050118729-A1 | Microarrays of cellulose binding chimeric proteins and methods of use thereof | ZEPHYR PROTEOMIX LTD. (IL) | 2005-06-02 | — | — | US | disclosed |
| WO-2005044981-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS, INC. (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005023981-A2 | LIBRARIES OF CHIMERIC CELLULOSE BINDING PROTEINS AND METHODS OF USE THEREOF | ZEPHYR PROTEOMIX LTD. (IL) | 2005-03-17 | — | — | WO | disclosed |
| WO-2003074722-A2 | MICROARRAYS OF CELLULOSE BINDING CHIMERIC PROTEINS AND METHODS OF USE THEREOF | ZEPHYR PROTEOMIX LTD. (IL) | 2003-09-12 | — | — | WO | disclosed |