SCHEMBL30995356

SCHEMBL30995356

COc1ccc(COc2c(F)cc(C(=O)NCC3CCC(c4noc(-c5ccnc(N6CCNCC6)n5)n4)CC3)c(F)c2F)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.36
NAPEPLD Q6IQ20 2/20 0.35
DKK1 O94907 1/20 0.35
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH2 P05091 1/20 0.34
CCNE1 P24864 1/20 0.34
CDK2 P24941 1/20 0.34
HTR4 Q13639 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
ACACB O00763 1/20 0.33
ACACA Q13085 1/20 0.33
GSK3B P49841 1/20 0.33
AURKA O14965 1/20 0.33
LCK P06239 1/20 0.33
MET P08581 1/20 0.33
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29318877 1.00 F10 (0.36) F10NAPEPLDDKK1HCRTR1HCRTR2
SCHEMBL30995328 0.90 TBK1 (0.40)
SCHEMBL29318880 0.90 TBK1 (0.40)
SCHEMBL30995457 0.82 CRBN (0.34)
SCHEMBL29319779 0.82 CRBN (0.34)
SCHEMBL30849252 0.82 PDE5A (0.32) ALDH1A1KDM4ECCNE1CDK2
SCHEMBL27213773 0.82 PDE5A (0.32) ALDH1A1KDM4ECCNE1CDK2
SCHEMBL27392871 0.82 PDE5A (0.32) ALDH1A1KDM4ECCNE1CDK2
SCHEMBL27392873 0.81 F10 (0.34) F10NAPEPLDDKK1ALDH1A1KDM4E
SCHEMBL27392867 0.78 DDB1 (0.36) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634169-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF Pfizer Inc. (US) 2025-10-22 EP disclosed
WO-2024127297-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF PFIZER INC. (US) 2024-06-20 WO disclosed