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SCHEMBL30995457

SCHEMBL30995457

COc1ccc(COc2c(F)cc(C(=O)NCC3CCC(c4noc(-c5ccnc(N6CCN(CCCc7ccc8c(c7)n(C)c(=O)n8C7CCC(=O)NC7=O)CC6)n5)n4)CC3)c(F)c2F)cc1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 5/20 0.34
▸ DDB1 Q16531 4/20 0.34
▸ EGFR P00533 7/20 0.33
▸ ERBB3 P21860 1/20 0.31
▸ ERBB2 P04626 1/20 0.30
▸ IKZF3 Q9UKT9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29319779 1.00 CRBN (0.34) CRBNDDB1EGFRERBB3ERBB2
SCHEMBL30995059 0.91 DDB1 (0.36) CRBNDDB1EGFR
SCHEMBL29319774 0.91 DDB1 (0.36) CRBNDDB1EGFR
Hydrochloric Acid SCHEMBL30969997 0.91 DDB1 (0.36) CRBNDDB1EGFR
SCHEMBL30995346 0.89 DDB1 (0.34) CRBNDDB1EGFRERBB3
SCHEMBL29319381 0.89 DDB1 (0.34) CRBNDDB1EGFRERBB3
Trifluoroacetic Acid SCHEMBL30970069 0.89 CRBN (0.34) CRBNDDB1EGFR
SCHEMBL30995356 0.82 F10 (0.36) —
SCHEMBL29318877 0.82 F10 (0.36) —
SCHEMBL30995361 0.79 CRBN (0.36) CRBNDDB1IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634169-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF Pfizer Inc. (US) 2025-10-22 — — EP disclosed
WO-2024127297-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF PFIZER INC. (US) 2024-06-20 — — WO disclosed