SCHEMBL30996182

SCHEMBL30996182

COc1ccc(-c2cccc(Br)c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 2/20 0.63
ABCB1 P08183 2/20 0.63
BCR P11274 2/20 0.63
HDAC4 P56524 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
GABRG2 P18507 1/20 0.53
GABRB3 P28472 1/20 0.53
GABRA5 P31644 1/20 0.53
GABRA3 P34903 1/20 0.53
ADORA2A P29274 1/20 0.51
ADORA1 P30542 1/20 0.51
CYP1A1 P04798 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2E1 P05181 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C8 P10632 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP2C9 P11712 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1181012 1.00 ABL1 (0.63) ABL1ABCB1BCRHDAC4HDAC2
SCHEMBL2648845 0.86 CYP3A4 (0.57) ABL1ABCB1BCRHDAC4HDAC8
SCHEMBL1180429 0.85 ABL1 (0.83) ABL1ABCB1BCRHDAC4HDAC2
SCHEMBL4757496 0.84 CYP1A1 (0.61) ABL1ABCB1BCRHDAC4HDAC8
SCHEMBL13682551 0.82 ALDH1A1 (0.52) GABRG2GABRB3GABRA5GABRA3CYP1A2
SCHEMBL578260 0.81 ADORA2A (0.47) ABL1ABCB1BCRHDAC4HDAC2
SCHEMBL22229667 0.81 ABL1 (0.59) ABL1ABCB1BCRCYP1A1CYP1A2
SCHEMBL792197 0.81 ABL1 (0.77) ABL1ABCB1BCRHDAC4HDAC2
SCHEMBL1180412 0.81 ABL1 (0.77) ABL1ABCB1BCRHDAC4HDAC2
SCHEMBL27649742 0.81 ABL1 (0.77) ABL1ABCB1BCRHDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324596-A Synthesis method of biaryl compound 新疆大学 2024-07-12 CN disclosed