SCHEMBL30997387

SCHEMBL30997387

C[C@H](F)[C@H](N)Cc1cc2c(NCc3ncccc3F)nc(Cl)nn2c1Br

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DYRK3 O43781 1/20 0.34
CLK1 P49759 1/20 0.34
DYRK1A Q13627 1/20 0.34
DYRK2 Q92630 1/20 0.34
DYRK4 Q9NR20 1/20 0.34
DYRK1B Q9Y463 1/20 0.34
ADORA2A P29274 10/20 0.32
ADORA2B P29275 10/20 0.32
ADORA1 P30542 10/20 0.32
KCNH2 Q12809 1/20 0.32
TLR7 Q9NYK1 1/20 0.32
ADORA3 P0DMS8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30948888 0.87 TP53 (0.36) ADORA1ADORA3
SCHEMBL30997368 0.83 KCNH3 (0.34)
SCHEMBL30948894 0.83 RXFP1 (0.37)
SCHEMBL30997365 0.82 PDE2A (0.33)
SCHEMBL30997398 0.81 KCNH3 (0.32)
SCHEMBL31030126 0.81
SCHEMBL31030127 0.81
SCHEMBL31030155 0.80 KCNN1 (0.38)
SCHEMBL31010618 0.80 TLR7 (0.30) TLR7
SCHEMBL31030122 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4651950-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2025-11-26 EP disclosed
WO-2024155842-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. (US) 2024-07-25 WO disclosed