Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13157920 | 1.00 | GPR183 (0.47) | GPR183LSSCHRM2CHRM3HRH3 | |
| SCHEMBL3099510 | 0.89 | GPR183 (0.58) | GPR183LSSHRH3TP53MBTD1 | |
| SCHEMBL13158155 | 0.89 | GPR183 (0.58) | GPR183LSSHRH3TP53MBTD1 | |
| SCHEMBL13157665 | 0.89 | GPR183 (0.58) | GPR183LSSHRH3TP53MBTD1 | |
| SCHEMBL13157929 | 0.85 | GPR183 (0.51) | GPR183LSSHRH3MBTD1L3MBTL3 | |
| SCHEMBL3089335 | 0.85 | GPR183 (0.51) | GPR183LSSHRH3MBTD1L3MBTL3 | |
| SCHEMBL13157699 | 0.84 | CHRNB2 (0.46) | CHRM2CHRM3ALDH1A1GAAAKR1C3 | |
| SCHEMBL3111417 | 0.84 | CHRNB2 (0.46) | CHRM2CHRM3ALDH1A1GAAAKR1C3 | |
| SCHEMBL13157747 | 0.82 | GPR183 (0.51) | GPR183LSSHRH3GAAMEN1 | |
| SCHEMBL3092717 | 0.82 | GPR183 (0.51) | GPR183LSSHRH3GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399455-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20100234356-A1 | COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234356-A1 | COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS | ACKR3, CCR5, CXCR2 | GPR183 72/4885LSS 3057/4885CHRM2 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.