Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491799 | 0.92 | CHRM2 (0.57) | EPHX1HDAC6ALDH1A1CHRM2HDAC3 | |
| Hydrochloric Acid SCHEMBL8495149 | 0.91 | CHRM2 (0.55) | EPHX1HDAC6ALDH1A1CHRM2HDAC3 | |
| SCHEMBL12639189 | 0.85 | HDAC6 (0.57) | EPHX1HDAC6ALDH1A1HDAC3HDAC1 | |
| SCHEMBL11779644 | 0.84 | MMP13 (0.49) | EPHX1CHRM2KMT2AMEN1LMNA | |
| SCHEMBL11779955 | 0.79 | MMP13 (0.47) | EPHX1CHRM2KMT2AMEN1LMNA | |
| SCHEMBL24168053 | 0.79 | EPHX1 (0.51) | EPHX1ALDH1A1SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL18177867 | 0.78 | POLB (0.69) | EPHX1ALDH1A1HDAC1POLBKMT2A | |
| SCHEMBL3099025 | 0.78 | POLB (0.69) | EPHX1ALDH1A1HDAC1POLBKMT2A | |
| SCHEMBL6610075 | 0.78 | MAPT (0.57) | EPHX1ALDH1A1SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL628651 | 0.78 | CHRM2 (0.72) | ALDH1A1CHRM2HDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765803-B1 | QUATERNARY SALT CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-09 | — | — | EP | disclosed |
| CN-101010312-B | Quaternary salt chemoattractant cytokine receptor 2 antagonists | JANSSEN PHARMACEUTICA NV | 2011-04-20 | — | — | CN | disclosed |
| US-7799824-B2 | Quaternary salt CCR2 antagonists | ORAPHARMA, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| CN-101010312-A | Quaternary salt chemoattractant cytokine receptor 2 antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | CN | disclosed |
| EP-1765803-A1 | QUATERNARY SALT CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-28 | — | — | EP | disclosed |
| US-20060293379-A1 | Quaternary salt CCR2 antagonists | KENVUE BRANDS LLC | 2006-12-28 | — | — | US | disclosed |
| WO-2006012135-A1 | QUATERNARY SALT CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N. V. (BE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293379-A1 | Quaternary salt CCR2 antagonists | CCR2, CCR1, CXCR2 | EPHX1 2083/4885HDAC6 280/4885ALDH1A1 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.