Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042474 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL31092659 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL31000147 | 0.81 | PIK3CA (0.50) | SMN1; SMN2PDE10AKDM4EALDH1A1MAPT | |
| SCHEMBL31000161 | 0.79 | PDE5A (0.42) | SMN1; SMN2ALDH1A1GAKLMNACNR2 | |
| SCHEMBL12002995 | 0.79 | SUV39H2 (0.41) | SMN1; SMN2ALDH1A1TSHRKMT2AGAK | |
| SCHEMBL16094409 | 0.75 | KMT2A (0.43) | SMN1; SMN2KDM4EMAPTCYP2C19KMT2A | |
| SCHEMBL31000267 | 0.75 | ENPP1 (0.36) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL27186472 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE10AKDM4EALDH1A1MAPT | |
| SCHEMBL24328594 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE10AKDM4EALDH1A1MAPT | |
| SCHEMBL31000328 | 0.72 | PRKDC (0.44) | SMN1; SMN2PDE10AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2025137567-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2025-06-26 | — | — | WO | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |