Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 11/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042474 | 0.83 | SMN1; SMN2 (0.46) | MEN1CYP1A2KMT2APDE5AENPP1 | |
| SCHEMBL31092659 | 0.83 | SMN1; SMN2 (0.46) | MEN1CYP1A2KMT2APDE5AENPP1 | |
| SCHEMBL31000090 | 0.79 | SMN1; SMN2 (0.53) | CYP1A2CYP2D6TSHRKMT2APDE5A | |
| SCHEMBL31000161 | 0.77 | PDE5A (0.42) | PDE5AGAKALDH1A1SMN1; SMN2 | |
| SCHEMBL31000267 | 0.73 | ENPP1 (0.36) | ENPP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20582119 | 0.68 | MALT1 (0.34) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7276406 | 0.68 | ENPP1 (0.73) | ENPP1 | |
| SCHEMBL4490992 | 0.68 | HTR3E (0.43) | SUV39H2HTR3EMEN1HTR3BCYP1A2 | |
| SCHEMBL25528793 | 0.67 | ALDH1A1 (0.41) | CYP1A2ALOX15ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL22441562 | 0.67 | ENPP1 (0.72) | ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148873-B1 | 4-ALKOXYPYRIDAZINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-29 | — | — | EP | disclosed |