Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000090 | 0.81 | SMN1; SMN2 (0.53) | PDE10ASMN1; SMN2KMT2AMAP2K7TRPM8 | |
| SCHEMBL31000282 | 0.79 | GAK (0.40) | PIK3CAMTORSMN1; SMN2GAKALDH1A1 | |
| SCHEMBL15652664 | 0.77 | PDE10A (0.51) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL26151191 | 0.75 | TRPM8 (0.52) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL31000304 | 0.75 | ENPP1 (0.39) | PIK3CAMTORALDH1A1 | |
| SCHEMBL14376035 | 0.72 | PDE10A (0.52) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL13678372 | 0.71 | PDE10A (0.51) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL13271359 | 0.71 | PDE10A (0.51) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL14349526 | 0.70 | PDE10A (0.47) | PIK3CAMTORPDE10ASMN1; SMN2KMT2A | |
| SCHEMBL24542664 | 0.70 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AKDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2025137567-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2025-06-26 | — | — | WO | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |