Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 14/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25338902 | 0.89 | EIF2AK4 (0.43) | EIF2AK4FLT3TRPV3 | |
| SCHEMBL31000078 | 0.88 | EIF2AK4 (0.46) | EIF2AK4HDAC4HDAC6TRPV1 | |
| SCHEMBL31000122 | 0.87 | EIF2AK4 (0.43) | EIF2AK4HDAC4HDAC6TRPV1FLT3 | |
| SCHEMBL24231691 | 0.82 | SYK (0.43) | EIF2AK4HDAC4HDAC6FLT3 | |
| SCHEMBL25989141 | 0.80 | FLT3 (0.52) | FLT3 | |
| SCHEMBL25992857 | 0.80 | FLT3 (0.52) | FLT3 | |
| SCHEMBL25998223 | 0.80 | FLT3 (0.52) | FLT3 | |
| SCHEMBL25989142 | 0.80 | FLT3 (0.52) | FLT3 | |
| SCHEMBL25335157 | 0.80 | EIF2AK4 (0.42) | EIF2AK4FLT3 | |
| SCHEMBL1995228 | 0.79 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |