Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13695275 | 0.90 | CTSL (0.53) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20401006 | 0.90 | CTSL (0.53) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13694941 | 0.90 | CTSL (0.53) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29401180 | 0.90 | CTSL (0.53) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30638167 | 0.90 | CTSL (0.53) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31037708 | 0.87 | CASP3 (0.53) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL26966023 | 0.87 | CASP3 (0.53) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL16822490 | 0.87 | CASP3 (0.53) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL25718153 | 0.87 | CASP3 (0.52) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25718152 | 0.87 | CASP3 (0.52) | CASP3KMT2ACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287138-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | MERCK SHARP & DOHME LLC | 2024-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287138-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | TNF, TNFRSF1A, CD40 | CASP3 418/4885KMT2A 4601/4885CYP3A4 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.