⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31084100 | 0.94 | PDE5A (0.32) | — | |
| SCHEMBL31084103 | 0.92 | — | — | |
| SCHEMBL31084089 | 0.88 | — | — | |
| SCHEMBL31083993 | 0.87 | PIK3R1 (0.31) | — | |
| SCHEMBL31002943 | 0.86 | — | — | |
| SCHEMBL31084088 | 0.86 | ALDH1A1 (0.35) | — | |
| SCHEMBL31084074 | 0.82 | PIK3R1 (0.32) | — | |
| SCHEMBL31083977 | 0.82 | PIK3R1 (0.31) | — | |
| SCHEMBL31084034 | 0.81 | TACR2 (0.32) | — | |
| SCHEMBL31084027 | 0.81 | TRPV3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4674852-A1 | PREPARATION METHOD FOR AND USE OF DIHYDROTHIENOPYRIMIDINE DERIVATIVE | Innovstone Therapeutics Limited (CN) | 2026-01-07 | — | — | EP | disclosed |
| CN-118871444-A | Preparation method and application of dihydro-thienopyrimidine derivative | 上海翊石医药科技有限公司 | 2024-10-29 | — | — | CN | disclosed |
| WO-2024179493-A1 | PREPARATION METHOD FOR AND USE OF DIHYDROTHIENOPYRIMIDINE DERIVATIVE | 上海翊石医药科技有限公司 | 2024-09-06 | — | — | WO | disclosed |
| CN-118146236-A | Substituted dihydrothienoazaheteroaryl derivatives, methods of preparation and use of prodrugs thereof | 上海翊石医药科技有限公司 | 2024-06-07 | — | — | CN | disclosed |