Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | DHPS | P49366 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29283816 | 1.00 | HSP90AB1 (0.53) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL31006516 | 0.92 | HSP90AB1 (0.57) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL29283795 | 0.92 | HSP90AB1 (0.57) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL29283797 | 0.90 | HSP90AB1 (0.51) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL31006556 | 0.90 | HSP90AB1 (0.51) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL29283811 | 0.87 | HSP90AB1 (0.69) | HSP90AB1ROCK2ROCK1ESR1ESR2 | |
| SCHEMBL31006525 | 0.87 | HSP90AB1 (0.53) | HSP90AB1ROCK2ROCK1HTR6BRD4 | |
| SCHEMBL29283875 | 0.87 | HSP90AB1 (0.53) | HSP90AB1ROCK2ROCK1HTR6BRD4 | |
| SCHEMBL31006530 | 0.86 | HTR6 (0.64) | HSP90AB1ROCK2ROCK1HTR6EGLN1 | |
| SCHEMBL29283812 | 0.86 | HTR6 (0.64) | HSP90AB1ROCK2ROCK1HTR6EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184635-A | Quinolinone compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2024-06-14 | — | — | CN | disclosed |