Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29283814 | 1.00 | THRB (0.43) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL29283860 | 0.91 | HSP90AB1 (0.46) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL31006542 | 0.91 | HSP90AB1 (0.46) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL29283800 | 0.91 | ESR1 (0.43) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL31006519 | 0.91 | ESR1 (0.43) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL29283809 | 0.90 | THRB (0.45) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL31006523 | 0.87 | GRM2 (0.47) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL29283862 | 0.87 | GRM2 (0.47) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL31006562 | 0.86 | THRB (0.42) | THRBLMNAMKNK1MKNK2TP53 | |
| SCHEMBL29283803 | 0.86 | THRB (0.42) | THRBLMNAMKNK1MKNK2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184635-A | Quinolinone compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2024-06-14 | — | — | CN | disclosed |