Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | GRIA2 | P42262 | 15/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112109 | 0.88 | CYP1A2 (0.44) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL3113696 | 0.87 | GRIA2 (0.51) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL3114522 | 0.86 | GRIA2 (0.53) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL13100006 | 0.85 | CA2 (0.50) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL3105055 | 0.84 | PTGS2 (0.47) | CYP1A2CYP2D6CYP2C19GRIA2CA2 | |
| SCHEMBL3113076 | 0.81 | GRIA2 (0.51) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL3103091 | 0.80 | GRIA2 (0.53) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL3102879 | 0.79 | GRIA2 (0.48) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL14292377 | 0.78 | GRIA2 (0.51) | CYP1A2CYP2D6CYP2C19GRIA2CYP2C9 | |
| SCHEMBL14292357 | 0.78 | CA2 (0.41) | CYP1A2CYP2D6CYP2C19CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | CA2, CA7, CA9 | CYP1A2 1112/4885CYP2D6 1483/4885CYP2C19 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.