Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 5/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30037309 | 1.00 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1EP300CFTRRET | |
| SCHEMBL31009665 | 1.00 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1EP300CFTRRET | |
| SCHEMBL31009573 | 0.81 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1CFTRSMN1; SMN2HPGD | |
| SCHEMBL31009581 | 0.81 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1CFTRSMN1; SMN2HPGD | |
| SCHEMBL31009677 | 0.80 | EP300 (0.37) | ALDH1A1L3MBTL1EP300CFTRCREBBP | |
| SCHEMBL31009656 | 0.79 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1EP300HPGDKDM4E | |
| SCHEMBL31009657 | 0.79 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1EP300HPGDKDM4E | |
| SCHEMBL31009616 | 0.77 | KDM5A (0.40) | ALDH1A1L3MBTL1EP300GLAMAPK1 | |
| SCHEMBL31009597 | 0.77 | KDM5A (0.40) | ALDH1A1L3MBTL1EP300GLAMAPK1 | |
| SCHEMBL31009606 | 0.77 | CREBBP (0.39) | ALDH1A1L3MBTL1NPC1RAB9ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246946-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246946-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | ALDH1A1 693/4885L3MBTL1 3434/4885EP300 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.