⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28979903 | 0.80 | ALDH1A1 (0.43) | — | |
| SCHEMBL19237019 | 0.80 | — | — | |
| SCHEMBL4664754 | 0.79 | GAA (0.89) | — | |
| SCHEMBL2365151 | 0.78 | ALDH1A1 (1.00) | — | |
| SCHEMBL14208207 | 0.77 | GAA (0.53) | — | |
| SCHEMBL12862600 | 0.77 | GAA (0.53) | — | |
| SCHEMBL12194202 | 0.76 | — | — | |
| SCHEMBL11983638 | 0.75 | ALDH1A1 (0.51) | — | |
| SCHEMBL11205163 | 0.75 | ALDH1A1 (0.51) | — | |
| SCHEMBL16050086 | 0.75 | GAA (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330066-A1 | Vasodilator and Use Thereof | BIORADICAL RESEARCH INSTITUTE CORP. (JP) | 2023-10-19 | — | — | US | disclosed |
| US-20230286921-A1 | Method for Manufacturing Compound | BIORADICAL RESEARCH INSTITUTE CORP. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20230286921-A1 | Method for Manufacturing Compound | BIORADICAL RESEARCH INSTITUTE CORP. (JP) | 2023-09-14 | — | — | US | disclosed |
| WO-2021125345-A1 | VASODILATOR AND USE THEREOF | 株式会社バイオラジカル研究所 | 2021-06-24 | — | — | WO | disclosed |
| US-20210128529-A1 | DRUG CONTAINING PYRAZOLONE DERIVATIVE | NOBELPHARMA CO., LTD. (JP) | 2021-05-06 | — | — | US | disclosed |
| CN-112533991-A | Rubber composition, rubber material, use thereof, and additive | 大塚化学株式会社 | 2021-03-19 | — | — | CN | disclosed |
| CN-112118839-A | Pyrazolone derivative-containing drug | 耐贝医药株式会社 | 2020-12-22 | — | — | CN | disclosed |
| WO-2020158225-A1 | ANTIOXIDANT AND USE THEREOF | 株式会社バイオラジカル研究所 | 2020-08-06 | — | — | WO | disclosed |
| EP-3666270-A1 | DRUG CONTAINING PYRAZOLONE DERIVATIVE | Nobelpharma Co., Ltd. (JP) | 2020-06-17 | — | — | EP | disclosed |
| EP-1793821-B1 | PYRAZOLONE COMPOUNDS FOR TREATING CEREBROVASCULAR DISORDERS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-10-31 | — | — | EP | disclosed |
| US-20040254234-A1 | Medicament for prevention and/or therapy of arterial wall disorder | MITSUBISHI PHARMA CORPORATION (JP) | 2004-12-16 | — | — | US | disclosed |
| EP-1437137-A1 | DRUGS COMPRISING COMBINATION OF ANTITHROMBOTIC AGENT WITH PYRAZOLONE DERIVATIVE | Mitsubishi Pharma Corporation (JP) | 2004-07-14 | — | — | EP | disclosed |
| US-RE35801-E | PYRAZOLONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5461155-A | Useful in dye diffusion transfer processes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-10-24 | — | — | US | disclosed |
| US-5314998-A | Dye-donor sheets for thermal printing | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0591016-A1 | Organic solvent-soluble metal-azo and metal-azomethine dyes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0208874-B1 | PROPHYLACTIC AND THERAPEUTIC AGENT FOR CIRCULATORY DISORDERS | MITSUBISHI KASEI CORPORATION (JP) | 1993-03-24 | — | — | EP | disclosed |
| US-4857542-A | INHIBITOR AGAINST LIPID PEROXIDATION | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0240001-A1 | 2-Pyrazolin-5-ones and a process for production thereof | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1987-10-07 | — | — | EP | disclosed |
| EP-0208874-A1 | Prophylactic and therapeutic agent for circulatory disorders | MITSUBISHI KASEI CORPORATION (JP) | 1987-01-21 | — | — | EP | disclosed |