Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760552 | 0.93 | MAPT (0.56) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL3229455 | 0.84 | PDE4B (0.41) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL3111324 | 0.78 | HTT (0.43) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL3102864 | 0.71 | GSK3B (0.43) | — | |
| SCHEMBL27957397 | 0.70 | MAPT (0.66) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL1779408 | 0.70 | MAPT (0.58) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL8240740 | 0.70 | MAPT (0.74) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL7292220 | 0.69 | ALDH1A1 (0.66) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL1077430 | 0.69 | MAPT (0.64) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 | |
| SCHEMBL1777652 | 0.68 | MAPT (0.62) | MAPTL3MBTL1HTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990343-B1 | Azaindoles | AVENTIS PHARMA LTD (GB) | 2012-04-04 | — | — | EP | disclosed |
| EP-1263759-B1 | AZAINDOLES | AVENTIS PHARMA LTD (GB) | 2010-09-08 | — | — | EP | disclosed |
| EP-1990343-A2 | Azaindoles | Aventis Pharma Limited (GB) | 2008-11-12 | — | — | EP | disclosed |