Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.39 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3111324 | 0.94 | HTT (0.43) | PDE4BL3MBTL1MAPTNPSR1HTT | |
| SCHEMBL3101413 | 0.84 | MAPT (0.52) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL2760552 | 0.78 | MAPT (0.56) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL3109176 | 0.74 | GSK3B (0.61) | PDE4B | |
| SCHEMBL1779585 | 0.73 | L3MBTL1 (0.45) | PDE4BL3MBTL1MAPTNPSR1HTT | |
| SCHEMBL1780510 | 0.72 | HTT (0.47) | PDE4BL3MBTL1MAPTNPSR1HTT | |
| SCHEMBL1777994 | 0.70 | IMPDH2 (0.56) | PDE4BL3MBTL1MAPTHTTMEN1 | |
| SCHEMBL1780399 | 0.69 | ALDH1A1 (0.64) | MAPTHTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL3113427 | 0.69 | GSK3B (0.59) | PDE4B | |
| SCHEMBL984866 | 0.67 | L3MBTL1 (0.47) | L3MBTL1MAPTNPSR1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990343-B1 | Azaindoles | AVENTIS PHARMA LTD (GB) | 2012-04-04 | — | — | EP | disclosed |
| EP-1263759-B1 | AZAINDOLES | AVENTIS PHARMA LTD (GB) | 2010-09-08 | — | — | EP | disclosed |
| EP-1990343-A2 | Azaindoles | Aventis Pharma Limited (GB) | 2008-11-12 | — | — | EP | disclosed |