Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25670611 | 1.00 | EGFR (0.46) | EGFRBRD4SIRT5MAPTSMN1; SMN2 | |
| SCHEMBL25670612 | 0.89 | PKMYT1 (0.43) | EGFRAURKAJAK2JAK1JAK3 | |
| SCHEMBL25669737 | 0.88 | PKMYT1 (0.52) | EGFRMAPK1AURKAJAK2JAK3 | |
| SCHEMBL25670608 | 0.86 | MAPT (0.47) | EGFRMAPTSMN1; SMN2ALOX15TSHR | |
| SCHEMBL25670653 | 0.75 | TYK2 (0.52) | EGFRMAPK1AURKAJAK2JAK1 | |
| SCHEMBL30465841 | 0.75 | TYK2 (0.52) | EGFRMAPK1AURKAJAK2JAK1 | |
| SCHEMBL30879124 | 0.74 | MAPT (0.70) | SIRT5MAPTSMN1; SMN2ALOX15TSHR | |
| SCHEMBL25670657 | 0.73 | KAT2B (0.52) | EGFRMAPK1AURKAJAK2JAK1 | |
| SCHEMBL30879367 | 0.73 | SIRT5 (0.64) | EGFRBRD4SIRT5MAPTSMN1; SMN2 | |
| SCHEMBL30878914 | 0.72 | MAPT (0.60) | BRD4SIRT5MAPTSMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118401516-A | TYK2 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |