Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 3/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073571 | 1.00 | CTSL (0.37) | CTSLCTSSCTSKCTSCACKR3 | |
| SCHEMBL24073572 | 1.00 | CTSL (0.37) | CTSLCTSSCTSKCTSCACKR3 | |
| SCHEMBL24073255 | 1.00 | CTSL (0.37) | CTSLCTSSCTSKCTSCACKR3 | |
| SCHEMBL24073582 | 0.90 | GPR6 (0.36) | ACKR3KCNH2USP30GPR6TLR9 | |
| SCHEMBL25839011 | 0.90 | GPR6 (0.36) | ACKR3KCNH2USP30GPR6TLR9 | |
| SCHEMBL24072843 | 0.90 | GPR6 (0.36) | ACKR3KCNH2USP30GPR6TLR9 | |
| SCHEMBL24072842 | 0.90 | GPR6 (0.36) | ACKR3KCNH2USP30GPR6TLR9 | |
| SCHEMBL25261516 | 0.89 | F2R (0.36) | ACKR3KCNH2GPR6F2RMEN1 | |
| SCHEMBL25837888 | 0.88 | CTSK (0.39) | CTSLCTSSCTSKCTSCACKR3 | |
| SCHEMBL24073256 | 0.86 | JAK2 (0.35) | ACKR3KCNH2GPR6F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-B1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | MISSION THERAPEUTICS LTD (GB) | 2024-07-03 | — | — | EP | disclosed |