SCHEMBL31018694

SCHEMBL31018694

O=C(Nc1ccc2cnn([C@@H]3CC3(F)F)c2n1)c1ccc(I)cc1N1CCC2(CC1)CC2

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31018629 1.00 KIF18A (0.43) KIF18A
SCHEMBL31018654 1.00 KIF18A (0.43) KIF18A
SCHEMBL31018532 0.91 KIF18A (0.44) KIF18A
SCHEMBL31500403 0.89 KIF18A (0.47) KIF18A
SCHEMBL31018709 0.89 HTR1F (0.34) KIF18A
SCHEMBL31018577 0.89 HTR1F (0.34) KIF18A
SCHEMBL31018586 0.87 KIF18A (0.42) KIF18A
SCHEMBL31018641 0.87 KIF18A (0.42) KIF18A
SCHEMBL31018570 0.84 KIF18A (0.43) KIF18A
SCHEMBL31018674 0.83 KIF18A (0.65) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024125626-A1 NITROGENOUS COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF NUPHASE THERAPEUTICS (HANGZHOU) LIMITED., CO. (CN) 2024-06-20 — — WO disclosed
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