Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31019211 | 0.91 | PDE10A (0.47) | PDE10ANCF1DDB1CRBNMKNK1 | |
| SCHEMBL30824493 | 0.91 | PDE10A (0.59) | PDE10ANCF1DDB1CRBNMKNK1 | |
| SCHEMBL31620776 | 0.82 | NCF1 (0.57) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL24092000 | 0.79 | MCHR1 (0.57) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL16666168 | 0.79 | NPC1 (0.56) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL29911218 | 0.79 | MCHR1 (0.57) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL9056686 | 0.78 | NPC1 (0.59) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL30406501 | 0.77 | MKNK1 (0.54) | PDE10AMKNK1MKNK2MAPK10 | |
| Hydrochloric Acid SCHEMBL8852766 | 0.76 | NPC1 (0.57) | PDE10ANCF1DDB1CRBNMCHR1 | |
| SCHEMBL7698523 | 0.75 | NPC1 (0.49) | PDE10ANCF1DDB1CRBNMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240245673-A1 | Papain-like protease (PLpro) inhibitors | PFIZER INC. (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240245673-A1 | Papain-like protease (PLpro) inhibitors | PREP, PEPD, ACE | PDE10A 2958/4885NCF1 3667/4885DDB1 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.