Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.57 |
| ▸ | FGB | P02675 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855430 | 1.00 | KMT2A (0.69) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL12469680 | 0.80 | HDAC1 (0.69) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL31020173 | 0.78 | MEN1 (0.62) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL11812974 | 0.78 | KMT2A (0.61) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL17714697 | 0.77 | KMT2A (0.53) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL9850421 | 0.77 | HSP90AA1 (0.65) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL18163920 | 0.77 | HSP90AA1 (0.80) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL13856507 | 0.77 | HSP90AA1 (0.80) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL17792862 | 0.77 | HSP90AA1 (0.93) | KMT2AMEN1KDM4EMAPTL3MBTL1 | |
| SCHEMBL18292338 | 0.76 | MAOA (0.60) | KMT2AMEN1KDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3866802-B1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2024-08-21 | — | — | EP | claimed |
| CN-112823006-B | Quinone reductase 2 inhibitors as neuroprotective agents | 杜克大学 | 2024-09-17 | — | — | CN | disclosed |