Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3102508 | 0.96 | PDPK1 (0.57) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL3100667 | 0.94 | PDPK1 (0.56) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL3103014 | 0.84 | PDPK1 (0.50) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL16975058 | 0.80 | HTT (0.44) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL3114173 | 0.77 | PDPK1 (0.59) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL16975093 | 0.75 | PDPK1 (0.49) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL3110843 | 0.75 | PDPK1 (0.56) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL25908842 | 0.75 | PDPK1 (1.00) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL17723212 | 0.75 | PDPK1 (0.49) | PDPK1KDM4ELMNAGAABCAT2 | |
| SCHEMBL13473578 | 0.75 | KDM4E (0.60) | PDPK1KDM4ELMNAGAABCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324227-B2 | Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof | FDC LIMITED (US) | 2012-12-04 | — | — | US | disclosed |
| EP-2257555-B1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | NAT CHEMICAL LAB (IN) | 2012-07-04 | — | — | EP | disclosed |
| EP-2257555-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | National Chemical Laboratory (IN) | 2010-12-08 | — | — | EP | disclosed |
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | FDC LIMITED | 2010-10-28 | — | — | US | disclosed |
| WO-2009109983-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | NATIONAL CHEMICAL LABORATORY (IN) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | ERG28, DPM1, CYP51A1 | PDPK1 918/4885KDM4E 3607/4885LMNA 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.