Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13718183 | 1.00 | NR1H2 (0.63) | NR1H2ESR2MAPTP2RY14ESR1 | |
| SCHEMBL31022135 | 0.95 | ESR2 (0.65) | NR1H2ESR2MAPTP2RY14ESR1 | |
| SCHEMBL13717406 | 0.87 | UCHL1 (0.57) | NR1H2ESR2P2RY14 | |
| SCHEMBL13717401 | 0.87 | UCHL1 (0.57) | NR1H2ESR2P2RY14 | |
| SCHEMBL7744185 | 0.87 | NR1H2 (0.67) | NR1H2ESR2ABHD6GPR119MAPK1 | |
| SCHEMBL25430802 | 0.86 | NR1H2 (0.61) | NR1H2ESR2MAPTESR1ABHD6 | |
| SCHEMBL30519086 | 0.86 | NR1H2 (0.61) | NR1H2ESR2MAPTESR1ABHD6 | |
| SCHEMBL27042724 | 0.86 | ESR1 (0.48) | NR1H2ESR2ESR1ABHD6CCR2 | |
| SCHEMBL1784590 | 0.84 | NR1H2 (0.67) | NR1H2ESR2MAPTESR1GPR119 | |
| SCHEMBL30752205 | 0.84 | NR1H2 (0.52) | NR1H2ESR2MAPTP2RY14JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4654970-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | Opna Bio SA (CH) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024159079-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | Opna Bio SA (CH) | 2024-08-02 | — | — | WO | disclosed |