Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30593270 | 0.95 | ESR2 (0.69) | NR1H2ESR2ABHD6MAPK1MEN1 | |
| SCHEMBL23124526 | 0.95 | ESR2 (0.69) | NR1H2ESR2ABHD6MAPK1MEN1 | |
| SCHEMBL31070535 | 0.90 | ABHD6 (0.63) | NR1H2ESR2ABHD6MAPK1UCHL1 | |
| SCHEMBL31021995 | 0.87 | NR1H2 (0.63) | NR1H2ESR2ABHD6MAPK1NAMPT | |
| SCHEMBL1784590 | 0.87 | NR1H2 (0.67) | NR1H2ESR2MAPK1MEN1KMT2A | |
| SCHEMBL13718183 | 0.87 | NR1H2 (0.63) | NR1H2ESR2ABHD6MAPK1NAMPT | |
| SCHEMBL8485212 | 0.86 | NR1H2 (0.62) | NR1H2ESR2ABHD6MAPK1MEN1 | |
| SCHEMBL30199347 | 0.85 | NR1H2 (0.55) | NR1H2ESR2MAPK1TMEM97SIGMAR1 | |
| SCHEMBL7804799 | 0.84 | ESR2 (0.71) | NR1H2ESR2ABHD6MAPK1MEN1 | |
| SCHEMBL21557603 | 0.84 | NR1H2 (0.60) | NR1H2ESR2MAPK1NAMPTUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |