SCHEMBL31026293

SCHEMBL31026293

O=C1Nc2c(ccc3ccccc23)C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.47
DAO P14920 2/20 0.47
DNMT1 P26358 1/20 0.47
NSD2 O96028 1/20 0.47
BCHE P06276 1/20 0.47
CASP3 P42574 1/20 0.45
CASP2 P42575 1/20 0.45
CASP7 P55210 1/20 0.45
CASP6 P55212 1/20 0.45
CASP8 Q14790 1/20 0.45
ALDH1A1 P00352 3/20 0.45
CYP1A2 P05177 2/20 0.45
HPGD P15428 2/20 0.45
CYP2C19 P33261 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HTT P42858 1/20 0.45
CDK5 Q00535 1/20 0.45
CDK5R1 Q15078 1/20 0.45
NCOA1 Q15788 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31026300 1.00 CES1 (0.47) CES1DAODNMT1NSD2BCHE
SCHEMBL31026294 1.00 CES1 (0.47) CES1DAODNMT1NSD2BCHE
SCHEMBL458053 1.00 CES1 (0.47) CES1DAODNMT1NSD2BCHE
SCHEMBL3200379 0.78 ALDH1A1 (0.40) DNMT1ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL6317220 0.78 ALDH1A1 (0.40) DNMT1ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL31531054 0.77 CES1 (0.51) CES1DAONSD2BCHECASP3
SCHEMBL21792472 0.75 SIRT2 (0.37) DAODNMT1ALDH1A1CYP1A2HPGD
SCHEMBL10566907 0.72 MAPT (0.53) CES1DAONSD2BCHECYP1A2
SCHEMBL31016527 0.72 MAPT (0.53) CES1DAONSD2BCHECYP1A2
SCHEMBL57037 0.71 DNMT1 (0.53) CES1DNMT1CASP3CASP2CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118420618-A D-A conjugated small molecule based on benzindole diketone unit and polymer, preparation method and application thereof 华南理工大学 2024-08-02 CN claimed
CN-118420618-A D-A conjugated small molecule based on benzindole diketone unit and polymer, preparation method and application thereof 华南理工大学 2024-08-02 CN disclosed