Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 6/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31028754 | 0.88 | AURKA (0.41) | KMT2AL3MBTL1AURKAPDPK1AURKB | |
| SCHEMBL18636734 | 0.78 | LMNA (0.53) | HSP90AA1HSP90AB1AURKAPDPK1AURKB | |
| SCHEMBL17832889 | 0.77 | CACNB4 (0.49) | HSP90AA1HSP90AB1KMT2AL3MBTL1AURKA | |
| SCHEMBL12119818 | 0.75 | AURKA (0.63) | HSP90AA1HSP90AB1AURKAPDPK1AURKB | |
| SCHEMBL30415159 | 0.75 | KMT2A (0.44) | KMT2AL3MBTL1EPHX2BTKGAA | |
| SCHEMBL30415164 | 0.75 | KMT2A (0.44) | KMT2AL3MBTL1EPHX2BTKGAA | |
| SCHEMBL31741685 | 0.75 | LMNA (0.57) | AURKAPDPK1AURKBBTKLMNA | |
| SCHEMBL12118769 | 0.73 | AURKA (0.63) | AURKAPDPK1AURKBBTKLMNA | |
| SCHEMBL12119179 | 0.73 | AURKA (0.63) | AURKAPDPK1AURKBBTKLMNA | |
| SCHEMBL12119518 | 0.73 | AURKA (0.63) | AURKAPDPK1AURKBBTKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024115549-A1 | ARYL- AND HETEROARYL-SULFONAMIDE DERIVATIVES AS CCR8 MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-06 | — | — | WO | disclosed |