Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432553 | 1.00 | NR1H2 (0.44) | NR1H2PARP1TNKS2PARP2TSHR | |
| SCHEMBL27432029 | 0.82 | NR1H2 (0.44) | NR1H2PARP1TNKS2PARP2TSHR | |
| SCHEMBL20139779 | 0.81 | TSHR (0.62) | NR1H2TSHRHTTMAPK1POLB | |
| SCHEMBL31028991 | 0.81 | HTT (0.42) | TSHRHTTPOLBKCNH2 | |
| SCHEMBL1231827 | 0.79 | GBA1 (0.44) | NR1H2TSHRHTTLIPGGBA1 | |
| SCHEMBL25419579 | 0.77 | NR1H2 (0.44) | NR1H2TSHRHTTBACE1POLB | |
| SCHEMBL30138845 | 0.77 | NR1H2 (0.44) | NR1H2TSHRHTTBACE1POLB | |
| SCHEMBL9968767 | 0.77 | NR1H2 (0.44) | NR1H2TSHRHTTBACE1POLB | |
| SCHEMBL10095059 | 0.77 | CKS1B (0.47) | NR1H2TSHRLIPGGBA1MAPK1 | |
| SCHEMBL20152906 | 0.76 | PARP1 (0.45) | NR1H2PARP1TNKS2PARP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638455-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024138048-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2024-06-27 | — | — | WO | disclosed |