SCHEMBL31031243

SCHEMBL31031243

Cn1cc(-c2ccc3c(c2)nc2cc(N4CC(OS(C)(=O)=O)C4)ccn23)cn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIT P10721 1/20 0.38
LRRK2 Q5S007 5/20 0.36
FLT3 P36888 2/20 0.35
MET P08581 3/20 0.34
TTK P33981 1/20 0.34
IRAK4 Q9NWZ3 1/20 0.34
CCNC P24863 1/20 0.33
CDK8 P49336 1/20 0.33
NTRK1 P04629 1/20 0.33
CSF1R P07333 1/20 0.33
NTRK3 Q16288 1/20 0.33
NTRK2 Q16620 1/20 0.33
PIM1 P11309 1/20 0.33
PIM2 Q9P1W9 1/20 0.33
FGFR1 P11362 2/20 0.33
FLT1 P17948 1/20 0.33
FGFR2 P21802 1/20 0.33
FGFR4 P22455 1/20 0.33
FGFR3 P22607 1/20 0.33
FLT4 P35916 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31031252 0.83 LRRK2 (0.48) KITLRRK2FLT3METPIM1
SCHEMBL21035280 0.76 MAPT (0.37) PIM1
SCHEMBL31031249 0.69 CYP2D6 (0.35)
SCHEMBL31031211 0.67 CYP2D6 (0.34)
SCHEMBL18838768 0.66 CYP2D6 (0.40)
SCHEMBL2162653 0.65 TLR9 (0.38)
SCHEMBL31031218 0.63 SUV39H2 (0.34)
SCHEMBL31031221 0.63 HTR3E (0.40) IRAK4FGFR1
SCHEMBL31031217 0.63 HTR3E (0.40) IRAK4FGFR1
SCHEMBL31031232 0.63 KCNH2 (0.34) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658651-A1 NOVEL COMPOUNDS FOR TAU IMAGING Eli Lilly and Company (US) 2025-12-10 EP disclosed
WO-2024163546-A1 NOVEL COMPOUNDS FOR TAU IMAGING ELI LILLY AND COMPANY (US) 2024-08-08 WO disclosed