Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31031662 | 0.85 | MAPT (0.47) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL6563416 | 0.81 | MAPT (0.55) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL20921174 | 0.79 | KDM4E (0.50) | MAPTRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL958660 | 0.79 | RAB9A (0.58) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL25220378 | 0.78 | SMN1; SMN2 (0.58) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL3962704 | 0.78 | KDM4E (0.48) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL16755302 | 0.78 | MAPT (0.53) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL3967968 | 0.78 | MEN1 (0.44) | MAPTRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL14075995 | 0.77 | ALDH1A1 (0.56) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL20982735 | 0.76 | ALDH1A1 (0.63) | MAPTRAB9AMAPK1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153077-A1 | HPK1 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 | 2024-07-25 | — | — | WO | disclosed |