Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29714609 | 0.90 | GPR119 (0.40) | HCRTR2GPR119SSTR1SSTR4 | |
| SCHEMBL30674679 | 0.85 | HCRTR2 (0.46) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31035010 | 0.85 | HCRTR2 (0.44) | HCRTR2GPR119 | |
| SCHEMBL31484574 | 0.84 | HCRTR2 (0.43) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27281206 | 0.84 | HCRTR2 (0.43) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27281217 | 0.79 | GHSR (0.42) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31484582 | 0.79 | GHSR (0.42) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31702741 | 0.79 | KMT2A (0.41) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30674546 | 0.78 | MEN1 (0.40) | HCRTR2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29939732 | 0.78 | HCRTR2 (0.66) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658660-A1 | MACROCYCLIC OREXIN RECEPTOR AGONISTS AND USES THEREOF | Jazz Pharmaceuticals Ireland Limited (IE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160822-A1 | MACROCYCLIC OREXIN RECEPTOR AGONISTS AND USES THEREOF | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2024-08-08 | — | — | WO | disclosed |