SCHEMBL31035343

SCHEMBL31035343

Cc1c(N2CCC(C)(C)CC2)oc2ccc(C(F)(F)F)cc2c1=O

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 14/20 0.40
AKT1 P31749 1/20 0.39
AKT2 P31751 1/20 0.39
AKT3 Q9Y243 1/20 0.39
AKR1B1 P15121 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
TBK1 Q9UHD2 1/20 0.37
PIK3CA P42336 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31035410 0.85 KDM4E (0.44) AKT1AKT2AKT3AKR1B1MEN1
SCHEMBL30081607 0.84 AKT1 (0.46) AKT1AKT2AKT3MEN1KMT2A
SCHEMBL31035236 0.77 PRKDC (0.42) AKT1AKT2AKT3MEN1KMT2A
SCHEMBL31035332 0.77 AKT1 (0.46) AKT1AKT2AKT3PIK3CA
SCHEMBL31035486 0.76 PIK3CA (0.47) AKT1AKT2AKT3PIK3CA
SCHEMBL30370972 0.73 PRKDC (0.36) AKT1AKT2AKT3MEN1KMT2A
SCHEMBL29003817 0.71 NPC1 (0.44) AKT1AKT2AKT3MEN1KMT2A
SCHEMBL31035280 0.70 NPC1 (0.51) MEN1KMT2A
SCHEMBL31035311 0.69 PRKDC (0.61) KMT2A
SCHEMBL31035356 0.68 PIK3CA (0.37) AKT1AKT2AKT3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4680612-A1 CHEMICAL COMPOUNDS AN2 Therapeutics, Inc. (US) 2026-01-21 EP disclosed
WO-2024192309-A1 CHEMICAL COMPOUNDS REACTIVE BIOSCIENCES, INC. (US) 2024-09-19 WO disclosed