Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31037915 | 1.00 | GRM2 (0.38) | GRM2TGFBR1MAPK14KDRCYP11B2 | |
| SCHEMBL31546233 | 0.82 | TGFBR1 (0.39) | TGFBR1MAPK14KDRCYP11B2 | |
| SCHEMBL31037920 | 0.82 | TGFBR1 (0.39) | TGFBR1MAPK14KDRCYP11B2 | |
| SCHEMBL31037903 | 0.78 | GRM2 (0.42) | GRM2TGFBR1MAPK14KDRCYP11B2 | |
| SCHEMBL31037922 | 0.78 | GRM2 (0.42) | GRM2TGFBR1MAPK14KDRCYP11B2 | |
| SCHEMBL31037909 | 0.77 | PARP1 (0.39) | TGFBR1MAPK14KDROPRM1OPRL1 | |
| SCHEMBL25099365 | 0.66 | TGFBR1 (0.39) | TGFBR1MAPK14KDR | |
| SCHEMBL21277973 | 0.65 | TGFBR1 (0.58) | TGFBR1MAPK14KDR | |
| SCHEMBL20074379 | 0.65 | TGFBR1 (0.58) | TGFBR1MAPK14KDR | |
| SCHEMBL31546235 | 0.65 | GRM2 (0.37) | GRM2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119731163-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-118666851-A | Condensed ring KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-09-20 | — | — | CN | disclosed |