Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546233 | 1.00 | TGFBR1 (0.39) | TGFBR1KDRTLR8MAPK14CYP11B2 | |
| SCHEMBL31037902 | 0.82 | GRM2 (0.38) | TGFBR1KDRMAPK14CYP11B2 | |
| SCHEMBL31037915 | 0.82 | GRM2 (0.38) | TGFBR1KDRMAPK14CYP11B2 | |
| SCHEMBL31037903 | 0.78 | GRM2 (0.42) | TGFBR1KDRMAPK14CYP11B2 | |
| SCHEMBL31037922 | 0.78 | GRM2 (0.42) | TGFBR1KDRMAPK14CYP11B2 | |
| SCHEMBL31037909 | 0.77 | PARP1 (0.39) | TGFBR1KDRMAPK14 | |
| SCHEMBL31546225 | 0.77 | TGFBR1 (0.38) | TGFBR1KDRMAPK14RPS6KB1 | |
| SCHEMBL31546234 | 0.65 | CCNT1 (0.38) | TGFBR1KDRMAPK14CYP11B2 | |
| SCHEMBL31546223 | 0.65 | TLR8 (0.36) | TLR8FBP1DDB1CRBNPIK3CB | |
| SCHEMBL25332311 | 0.65 | DDB1 (0.57) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666851-A | Condensed ring KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-09-20 | — | — | CN | disclosed |