SCHEMBL31038657

SCHEMBL31038657

COc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.68
PHLPP2 Q6ZVD8 2/20 0.56
ADORA2A P29274 1/20 0.56
CYP19A1 P11511 1/20 0.56
KMT2A Q03164 3/20 0.55
TDP1 Q9NUW8 3/20 0.55
MEN1 O00255 2/20 0.55
MBNL1 Q9NR56 1/20 0.54
APP P05067 2/20 0.51
MAPT P10636 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
USP2 O75604 2/20 0.50
TP53 P04637 2/20 0.50
CYP3A4 P08684 2/20 0.50
CASP1 P29466 2/20 0.50
CASP7 P55210 2/20 0.50
HBB P68871 2/20 0.50
HSD17B10 Q99714 2/20 0.50
AURKA O14965 1/20 0.50
AURKB Q96GD4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2448633 1.00 KDM4E (0.68) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL30603139 1.00 KDM4E (0.68) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL14126140 0.95 KDM4E (0.62) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL31500228 0.95 KDM4E (0.61) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL20535915 0.94 KDM4E (0.62) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL11194565 0.92 KDM4E (0.61) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL9594726 0.92 KDM4E (0.57) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL12285138 0.88 KDM4E (0.55) KDM4EKMT2AMEN1APPHSD17B10
SCHEMBL31500219 0.87 KDM4E (0.53) KDM4EPHLPP2ADORA2ACYP19A1KMT2A
SCHEMBL6778691 0.86 APP (0.69) KDM4EPHLPP2ADORA2ACYP19A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119932188-A Methods for prostate cancer detection and treatment 液体活检研究有限责任公司 2025-05-06 CN disclosed
CN-112673115-B Methods for prostate cancer detection and treatment 液体活检研究有限责任公司 2025-02-18 CN disclosed
CN-118910259-A Predictive peptide receptor radiation therapy using gene expression assays 液体活检研究有限责任公司 2024-11-08 CN disclosed
CN-111479931-B Predictive peptide receptor radiation therapy using gene expression assays 液体活检研究有限责任公司 2024-08-16 CN disclosed