Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.56 |
| ▸ | LCK | P06239 | 15/20 | 0.56 |
| ▸ | EGFR | P00533 | 7/20 | 0.56 |
| ▸ | BTK | Q06187 | 7/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039885 | 0.90 | BTK (0.52) | JAK3LCKEGFRBTK | |
| SCHEMBL21946352 | 0.89 | JAK3 (0.63) | JAK3LCKEGFRBTK | |
| SCHEMBL21855211 | 0.86 | JAK3 (0.66) | JAK3LCKEGFRBTK | |
| SCHEMBL31039917 | 0.85 | LCK (0.51) | JAK3LCKEGFRBTK | |
| SCHEMBL30011366 | 0.85 | JAK3 (0.60) | JAK3LCKEGFRBTK | |
| SCHEMBL21946802 | 0.85 | JAK3 (0.60) | JAK3LCKEGFRBTK | |
| SCHEMBL21946354 | 0.84 | JAK3 (0.56) | JAK3LCKEGFRBTKCCND3 | |
| SCHEMBL30011108 | 0.83 | JAK3 (0.61) | JAK3LCKEGFRBTK | |
| SCHEMBL21946733 | 0.81 | JAK3 (0.64) | JAK3LCKEGFRBTK | |
| SCHEMBL25603497 | 0.80 | JAK3 (0.62) | JAK3LCKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955473-A | Difunctional compounds for degrading BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-113412259-B | Difunctional compounds for degrading BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2024-07-16 | — | — | CN | disclosed |