Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655537 | 1.00 | USP2 (0.50) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL8891920 | 0.92 | USP2 (0.48) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL18259604 | 0.92 | USP2 (0.48) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL20516006 | 0.92 | USP2 (0.48) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL23877994 | 0.89 | USP2 (0.50) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL22168315 | 0.89 | USP2 (0.50) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL304803 | 0.88 | USP2 (0.53) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL304804 | 0.88 | USP2 (0.53) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL8904969 | 0.88 | USP2 (0.53) | USP2SMN1; SMN2RECQLNR1H2MAPT | |
| SCHEMBL553919 | 0.88 | USP2 (0.53) | USP2SMN1; SMN2RECQLNR1H2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570672-B2 | Macrocyclic compounds and methods of use | AMGEN INC. | 2026-03-10 | — | — | US | disclosed |
| US-20250304599-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2025-10-02 | — | — | US | disclosed |
| US-20250236631-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2025-07-24 | — | — | US | disclosed |
| US-20240294551-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2024-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250236631-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | USP2 3635/4885SMN1; SMN2 3059/4885RECQL 90/4885 |
| US-12570672-B2 | Macrocyclic compounds and methods of use | KRAS, NRAS, BRAF | USP2 3246/4885SMN1; SMN2 1780/4885RECQL 721/4885 |
| US-20250304599-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | USP2 3635/4885SMN1; SMN2 3059/4885RECQL 90/4885 |
| US-20240294551-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | USP2 3635/4885SMN1; SMN2 3059/4885RECQL 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.